This single oral dosage delivery system, which involves inserting a smaller pre-filled capsule into a larger liquid-filled capsule, offers numerous possibilities and a broad range of formulation and design options.
DUOCAP® capsules can be used for immediate release or combined release—for example solubilized prebiotics in the outer capsule and probiotics in the inner capsule. The prebiotic releases immediately and the probiotic release later.
The inner capsule of this unique delivery system can contain liquid, semi-solids, powder or pellets, while the outer capsule can be either a liquid or semi-solid formulation.
The outer capsule typically is used for immediate release of a combination product or first phase of a dual release formulation. The liquid or semi-solid formulation of the outer capsule provides fast liquid release of the ingredient. Lipid-based formulations in either the inner and/or outer capsules may be developed to improve the bioavailability of the formulation.
Lonza has extensive experience in formulating combination products with incompatible compounds and with timed supplementation