Accelerating Lipid-Based Drug Formulation Through Application of an Expert System

Formulation scientists have become pivotal to pharmaceutical development, in that they are often faced with the daunting challenge of not only identifying the most suitable drug delivery platform among a myriad of options, but also developing and validating robust systems that address the challenges posed by increasingly complex drug candidates, in ever shortening time frames. Among these platforms, lipid-based formulations have become a well-established strategy that has been shown to improve the bioavailability and reduce the food effects or variability of poorly soluble compounds. Capsugel has developed a new strategy that moves beyond predictive modeling and excipient high throughput screening, utilizing an expert system based on experimental data that generates phase diagram output packages and provides unique formulation development support as well as increased speed to market.

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