Amorphous Dispersions and Other Tools for Drug Discovery Formulation Support

This paper describes broadly applicable formulation approaches and biomodeling tools that have been successfully used to improve the solubility and in vivo performance of low-solubility compounds—an increasingly larger component of compounds within pharmaceutical industry pipelines. The approaches, including spray-dried drug/polymer dispersions and drug/polymer nanoparticles, are ideally suited for use early in the drug-development process from discovery through formulation and toxicology screening. The approaches are readily scalable, facilitating progression of compounds through commercial manufacture.

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