Cross Linking of Gelatin Capsules and Its Relevance to Their In Vitro-In Vivo Performance

This white paper deals with the chemistry of gelatin crosslinking under conditions that are relevant to pharmaceutical situations. Mechanistic reationalizations are offered to explain gelatin crosslinking under "stress" conditions. These include elevated temperature, high humidity conditions and chemicals interactions between gelatin and aldehydes and other formulations excipients.

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