Using polymeric precipitation inhibitors to improve the absorption of poorly water-soluble drugs: A mechanistic basis for utility

The inclusion of certain polymers within solid dispersion or lipid-based formulations can maintain drug supersaturation after dispersion and/or digestion of the vehicle, leading to improvements in bioavailability and variability in exposure. This paper presents an overview of the fundamental principles of drug precipitation mechanisms, the mechanisms by which precipitation may be inhibited, the methods to identify polymeric precipitation inhibitors, and current literature evidence of the most‑effective inhibitors.