AAPS 2015 Poster - Modified Release - W4158 - Prolonged Gastric Acid Resistance Using a New Double Hypromellose Capsule Approach

Capsugel® DRcaps™, HPMC based capsules developed by Capsugel, are well accepted non-animal acid resistant two piece hard capsules. Extending the time post-dosing at which drug is released from a capsule can potentially help sitespecific drug delivery. The aim of this study was to evaluate the benefit of Capsugel® DRcaps™ capsule acid resistance in a double capsule concept and extend the period of delayed release.